Abstract
The current trend in sepsis treatment follows international guidelines. However, the contribution of Japan to these guidelines has been quite limited. In contrast to the increase in the number of publications from the other countries, the number of publications from Japan has shown a tendency to decrease in recent years. Sepsis research in Japan comprises a comparatively small percentage of human studies. Especially, the limited number of randomized controlled trial is a problem. Since an increase in the quality of Japanese research has been estimated from recent journal rankings, it is suggested that we can contribute to the production of international guidelines more efficiently by performing infrastructural preparation that can provide high quality clinical research such as large-scale multi-institutional studies.
