Abstract
Inoculating the pure line baby mice's brain with epidemic hepatitis virus, the author studied their peripheral blood pictures and bone marrow pictures in the course of the experiment, the following results have been obtained.
(1) In the peripheral blood, in the period of the attack of the disease, erythrocytes decreased in small number and hemogrobins showed a slight decrease in quantity.
In the period of the attack of the disease, the total number of leucocytes decreased clearly under the influence of the change of the number of lymphocytes besides neutrophil cells decreased in the absolute value and their clear trasition toward the left of the nuclei was observed.
Eosinophil. cells decreased or disappeared in the period of the attack of the disease and increased in the convalescence. Monocytes, plasma cells and reticulum cells increased after the latter period of the attack of the disease.
Comparing these blood pictures with those of men attacked by epidemic hepatitis, the rise and fall of the total number of leuocytes was same but neutrophil cells took the principal part in the case of men and lympnocytes did the principal part in the case of mice. The rise and fall of the other cells was same in men and mice.
(2) In the bone marrow pictures, in the period of the attack of the disease, the number of nucleated cells decreased remarkably. Erythroblast cells, lymphocytes and neutrophil cells decreased as well as nucleated cells did. No clear changes were observed in the eosinophil cells but monocytes, plasma cells and reticulum cells increased in a few number after the latter peroid of the attack of the disease.Next, both miotic and amiotic cells showed the slight relatiye increase in the period of the attack of the disease. Comparing these changes with those of men attacked by epidemic hepatitis, the same changes in the course were observed in the cells but in lymphocytes.
(3) Opposing the peripheral blood pictures of mice to the bone marrow pictures of mice, the changes of the total number of leucocytes, the number of nucleated cells, and each neutrophil cells, lymphocytes, monocytes and plasma cells were same in the coures of the disease.
Only eosinophil cells, which disappared ih the peripheral blood in the period of the attack of the disease decreased in a few number in the bone marrow even in the same period.
