Studies on the rh′ (C) Factor and Related Factors of the Rh System

Abstract

Data has been presented which indicate that blccds of the phenotypes c^v, rh^G (G), and rh′^N (C^N) closely resemble one another. A similarity was shown by the use of anti rhi (Ce) serum which did not agglutinate any of those invsstigated in this study. These bloods may be further classified according to their titration scores with anti-rh′ (C) and anti-hr" (e) sera. The generic agglutinogen notation, rh^G, has been retained with attached modifiers indicating the nature of the differences between rh^G bloods. In order to explain the failure of anti-rh_i (Ce) serum to agglutinate rh^G, bloods, a hypothesis has been evolved which embodies Wiener's concepts of the Rh agglutinogen and its associated blood factors. This theory supposes that the rh′ (C) and hr" (e) factors are co-extensive with another upon the same agglutinogen molecule and that anti-rh_i (Ce) is directed against receptors of each of them.