抄録
In the 2005 WHO classification, odontogenic keratocysts were divided into keratocystic odontogenic tumors (KCOTs) and orthokeratinized odontogenic cysts (OOCs). KCOT was considered to be a characteristic of nevoid basal cell carcinoma syndrome (NBCCS). It has been pointed out that the high recurrence rate of NBCCS is attributable to genetic influence. In the present study, we examined the clinicopathological and histopathological differences between KCOT and OOC, and furthermore compared the KCOT of NBCCS with non-NBCCS.
Methods: Thirty-five cases of KCOT and 10 cases of OOC were examined. Immunohistochemical detection was performed using antibodies against podoplanin, bcl-2, CK14 and CK19.
Results: The clinicopathological features of both lesions were largely consistent with those reported previously. Recurrence was found in the five KCOTs that were associated with NBCCS. On the other hand, OOCs showed no recurrence. In the KCOTs, daughter cysts, budding basal cell proliferation and epithelial nests were histopathologically evident. Immunohistochemical reactivity for podoplanin and bcl-2 was detected in the basal cell membrane and cytoplasm of most cells in the basal and suprabasal layers in KCOTs of non-NBCCS. In NBCCS, strong reactivity was observed in the cell membrane and cytoplasm of most cells in the basal and suprabasal layers. CK14 was detected in the epithelial layer of OOCs.
Discussion: Clinicopathological and histopathological findings were similar to those documented in previous reports. And immunohistochemical findings suggest that KCOTs have the characteristics of a tumor.
Conclusion: These findings suggested that KCOTs have tumor-like characteristics, and are different from OOCs.
