Trisomy 8 contributing to the diagnosis　of juvenile　intestinal　Behcet's　disease．

Abstract

We　report　a　12-year-old　boy　with　juvenile　intestinal　Behcet’s　disease．　He　presented　with　fever　and　oral aphtha　repeatedly　from　early　childhood　and his　blood　examination　often　showed　an　inflammatory　reaction．　But no　bacteria　were　found　in　any　bacteriological　examination．CT，　MRI　and　scintigram　of　the　whole　body　were normal．his　bone　marrow　chromosomal　test　revealed　trisomy　8（47XY，＋8［19］/46XY［1］），raising　suspicion　of the　presence　of　intestinal　Behcet's　disease．　Endoscopy　revealed　several　circular　ulcers　in　his　distal　esophagus and　ileocecal　region．　He　was　diagnosed　as　intestinal　Behcet's　disease　with　accompanying　trisomy　8． Myelodysplastic　syndrome（MDS） which　often　complicates　trisomy　8　was　not　observed　in　his　bone　marrow． 　　　This　was　a　rare　case　in　which　the　marrow　chromosome　abnormalities　led　to　the　diagnosis　of the　cause　of an　unknown　fever．　In　addition　it　is　very　interesting　case　in　terms　of　studying　the　pathogenic　mechanism　of intestinal　Behcet’s　disease．