2015 Volume 6 Issue 1 Pages 63-67
It is extremely rare that Behcet's disease arises as a complication of nephrotic syndrome（NS）． The case described herein is that of a l3-year-old boy． NS onset occurred at six years old, progressing to frequently relapsing NS． However， mizoribin（MZR）high-dose therapy can achieve long-term remission． He came to repeat erythema and stomatitis from MZR high-dose therapy． Orthodontic therapy had been started． He was diagnosed as having Behcet's disease taking the ocular attack as an opportunity 7 years after NS development． Human lymphocyte antigen（HLA）typing was positive for HLA-B51． The causes of Behcet’s disease and NS remain unclear． ln this case， therapeutic agents including steroids and MZR， as well as HLA and oral mucosal irritation， might have affected Behcet's disease development． This extremely interesting case is useful to elucidate the pathogenic mechanism of Behcet's disease．
