Abstract
The present case report describes a 14-year-old girl with systemic lupus erythematosus（ SLE）. She
presented with butterfly-shaped erythema, oral ulcers, joint pain, proteinuria, pericarditis, leukopenia,
elevated anti-dsDNA-, anti-Sm-, and antiphospholipid antibodies, and low complement, and was antinuclear
antibody-positive. As she had a cough and bloody sputum on admission, alveolar hemorrhage syndrome was
suspected. Therefore, she underwent two courses of steroid pulse therapy, and her symptoms of SLE
promptly improved.
International Society of Nephrology class Ⅲ （A/C） lupus nephritis was diagnosed according to
kidney biopsy results. Due to the possibility of diffuse alveolar hemorrhage, she underwent ovarian tissue
cryopreservation to preserve her fertility and cyclophosphamide pulse therapy was initiated four days after.
Young women with cancer undergo ovarian tissue cryopreservation when treated with alkylating
agent； however, this is the second report of cryopreservation of ovarian tissue for SLE in Japan.
SLE affects young women at a high rate； therefore, female patients with SLE should be presented
with the option of ovarian tissue cryopreservation before cyclophosphamide pulse therapy.
