PHOSPHORYLATION OF CITRULLINE WITH CYCLO-TRIPHOSPHATE IN AQUEOUS SOLUTION

Hideko Maeda; Tomoaki Kita; Takayuki Iiduka; Mitsutomo Tsuhako; Hiroyuki Nariai; Hirokazu Nakayama

doi:10.3363/prb.28.6

Hideko Maeda, Tomoaki Kita, Takayuki Iiduka, Mitsutomo Tsuhako, Hiroyuki Nariai, Hirokazu Nakayama

著者情報

キーワード: Phosphorylation, Citrulline, cyclo-Triphosphate, HPLC, ³¹P NMR

ジャーナルフリー

2013 年 28 巻 p. 6-9

DOI https://doi.org/10.3363/prb.28.6

詳細

抄録

Phosphorylation of citrulline (Cit) has been achieved using inorganic cyclo-triphosphate (P_3m) in aqueous solution. The optimum condition for the phosphorylation of Cit with P_3m is Cit : P_3m = 1.75 M : 0.5 M, pH 12 and 10°C. N²-(Phosphono)citrulline was synthesized with the yield of more than 85 %. The reaction mechanism of Cit with P_3m was discussed.

責任著者(Corresponding author)

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