PHOSPHONYLATION OF INOSINE WITH SODIUM DIPHOSPHONATE IN AQUEOUS SOLUTION

Hideko Maeda; Yukina Atarashi; Chikako Nakayama; Hiromi Nishida; Hiroyuki Nariai; Hirokazu Nakayama

doi:10.3363/prb.29.1

Hideko Maeda, Yukina Atarashi, Chikako Nakayama, Hiromi Nishida, Hiroyuki Nariai, Hirokazu Nakayama

著者情報

キーワード: Phosphonylation, Inosine, photocatalytic activity, Diphosphonate, HPLC, 31P NMR

ジャーナルフリー

2014 年 29 巻 p. 1-5

DOI https://doi.org/10.3363/prb.29.1

詳細

抄録

Phosphonylation of inosine (Ino) has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of Ino with DP is Ino : DP = 1 : 10, pH 11 and 10 °C. 2´-Phosphonylinosine and 3´-phosphonylinosine were synthesized with the total yield of more than 95 %. The phosphonylated products of Ino were stable at 10 °C and pH 9. The reaction mechanism of Ino with DP was discussed.

責任著者(Corresponding author)

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