Phosphorus Research Bulletin
Online ISSN : 1882-2363
Print ISSN : 0918-4783
ISSN-L : 0918-4783
INTRODUCTION OF PHOSPHATE GROUP INTO β-ARBUTIN BY CYCLO-TRIPHOSPHATE
Hideko MaedaMako KatsushiroHiroyuki NariaiHirokazu Nakayama
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2017 年 33 巻 p. 21-25

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Phosphorylation of β-arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of β-arbutin with P3m is β-arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40°C. 4-Triphospho-β-arbutin was synthesized with the yield of 90%. The reaction mechanism of β-arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated β-arbutin is expected that the permeability of β-arbutin into the skin will be increased by introducing a phosphate group.

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© 2017 Japanese Association of Inorganic Phosphorus Chemistry
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