COMPLEX FORMATION BETWEEN Na CHONDROITIN-6-SULFATE AND ACIDIC AROMATIC COMPOUNDS ON THE SURFACE OF HYDOXYAPATITE IN AN AQUEOUS PHASE

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Sodium benzoate(SB) and sodium salicylate(SS) were bound to sodium chondroitin-6-sulfate(NaChs) through dipole-ion interaction and hydrogen bonding, but they were not adsorbed directly to hydroxyapatite(HAP). NaChs was adsorbed on HAP through 2 mechanisms; one is due to electrostatic attractive force between surface Ca²⁺ and negatively charged group of NaChs, and the other owing to isomorphous substitution of sulfate group of NaChs for surface phosphate group of HAP. SB and SS non-adsorbable to HAP were adsorbed indirectly to HAP by virtue of dipole-ion interaction and hydrogen bonding with the adsorbed NaChs. NaChs captured more SB and SS on HAP than in an aqueous phase.