The variation of drag coefficient CD in multi-phase flow was investigated by using a series of measurements in a perpendicular rectangle duct. Several kinds of granular material of different diameter/specific gravity were used in the experiments.The following were found: as concentration C increases, CD increases slowly below C/Co of approximately 0.90, and rapidly above the value. Based on the experimental results, an equation to evaluate CD in multi-phase flow wasproposed. It is inversely proportional to the n-th power of porosity η, void ratio of granular material, and n is the function of velocity particle Reynolds' number Rd (=urd/υ).