Fabrication of biodegradable microneedle using thermal nanoimprint

Abstract

In the medical field, minimally invasive microneedles are required to reduce the physiological and psychological burden on patients. Then, we had attempted molding of polylactic acid, which is biodegradable material, using nanoimprint technique which has high productivity and fine formability. As a result, fine transcription could be achieved using Nickel plating mold of microneedle at vacuum state, 20MPa pressure, and 155°C temperature.