抄録
Recent studies have suggested that physical training after brain insults improves motor functions. The purpose of this study is to investigate the effect of treadmill training on intracerebral hemorrhage (ICH) model rats. Collagenase (1.4 μl of 200 U/ml) was injected into the left striatum in adult Wistar rat. ICH model rats received treadmill training (speed: 9 m/min, for 30 min per day) everyday from 4 day after ICH (D4) to D14. Motor function was evaluated at 24 h, D3, D7, D14, D21, D28, D35 and D42 by four behavioral tests: spontaneous ipsilateral rotation, beam walking ability, forepaw grasp, hindlimb retraction. Each test was scored from 0 (normal) to 3 (severe): total score was 0-12. We found that total score at D14 was low in training-group compared to ICH only (control), indicating that recovery of disturbed motor function was improved by treadmill training. Especially, recovery of forepaw function was improved at D14. The positive effect of treadmill training was detected till D21, but thereafter the score was not decreased further. We further investigated the effect of longer-term training (from D4 to D21) on ICH. Longer-term training had no further recovery of motor function. Data suggest that treadmill training from D4 to D14 could improve the recovery of forepaw motor function. [Jpn J Physiol 54 Suppl:S182 (2004)]
