抄録
We evoked neural activity in the cerebral cortex with either electrical or mechanical stimulation of the whisker area in the face. Changes of local blood flow associated with neural activity were analyzed in the rat cerebral cortex on the ipsilateral side. Neural activities were confirmed by measuring fluorescence with voltage-sensitive dye (RH795) or recording electric field potentials. On the ipsilateral side neural resposes were relatively weaker and had a longer delay than those on the contralateral side. Using 605, 585 or 577nm light we focused on dynamic changes in total amount of Hb(HbT), deoxy-Hb(HbR) or oxy-Hb(HbO) concentration. When observed with 605nm light, the response showed a biphasic time course; an initial decrease of reflection light (initial dip: ID) and following its increase on both sides. Compared with the contralateral side, changes of HbR or HbO concentration in the ipsilateral side were smaller both in area and in magnitude of their response, and showed longer delay. Also there are some other differences of their time course between contra- and ipsi-lateral cerebral cortex. [Jpn J Physiol 54 Suppl:S192 (2004)]
