抄録
The sympathetic nervous system has been purported to respond in a massive and generalized manner. However, in the present study, we demonstrated that intravenous administration of 2DG resulted in regional differences in sympathetic nerve activity in conscious rats. Wistar rats were instrumented chronically with electrodes for the measurements of renal (RSNA) and lumber (LSNA) sympathetic nerve activity, electroencephalogram (EEG), electrocardiogram and electromyogram; and catheters for systemic arterial and central venous pressures. At least 2 days after surgery, the changes in RSNA and LSMA were measured simultaneously and continuously before and after intravenous administration of the 2DG (750mg/kg) which resulted in an immediate reduction in both RSNA and LSNA; however, RSNA increased while LSNA remained lower thereafter. The time course of changes in the theta component (6-9 Hz) of the EEG showed a similar pattern with those changes in the RSNA. Heart rate decreased in a sustained fashion to 2DG. The results demonstrate a case in which the sympathetic nervous system responds in a non-uniform and differential manner. Moreover, it is suggested that the RSNA seemed to be functionally related to theta activity of the EEG. [Jpn J Physiol 54 Suppl:S202 (2004)]
