抄録
The purpose of the present study is to elucidate the effects of iron-deficiency (ID) on the numbers of neutrophil, monocyte, basophil, eosinophil and lymphocyte, and the weights of perirenal and periepididymal adipose tissues in rats. Male 6 weeks old Sprague Dawley rats (n=16) were used and divided into the control (CON: iron intake=6.1mg/day) and the ID-food (IDF: iron intake=0.05mg/day) groups. The durations of ID-feeding were maintained for 23 days. Tail venous white blood cells were analyzed by a cell counter apparatus. Numbers of total white blood cells and neutrophil in the IDF increased markedly from 15th days. Eosinophil and monocyte numbers in the IDF group increased relatively in 7-21 th days of ID-feeding, as compared with the those of CON. Lymphocyte numbers decreased markedly in 15-23 th days of ID-feeding. Basophil numbers did not change with ID-feeding. These results are similar with results obtained by the administration of β2-agonist, clenbuterol (1.0mg/kg BW/day). Further, the weights of perirenal and periepididymal adipose tissues per body weight in the IDF group were 2.12 and 1.44 times, respectively significantly higher than those of the CON. The IDF increased total white blood cells, neutrophils, eosinophil and monocyte numbers and decreased lymphocyte numbers without changing basophil numbers. These results suggest that iron-deficient food intake increases the numbers of natural immunity cells and decreases the numbers of acquired immunity cells in rats. [Jpn J Physiol 55 Suppl:S111 (2005)]
