抄録
Neural stem cells (NSCs) are defined as self-renewing, multipotent progenitor cells that give rise to the diverse types of neurons, astrocytes and oligodendrocytes in the central nervous system. The cell-lineage-specific fate is defined by spatial and temporal gene expression regulated by various transcription factors and intermediary co-regulators designated as coactivators and corepressors. We recently demonstrated that steroid receptor coactivator (SRC-1), which was identified to be nuclear proteins interacting with DNA-bound steroid receptors to potentiate their transcriptional efficiency, was highly expressed in the central nervous system at embryonic stages and the disruption of SRC-1 caused the delayed Purkinje cell development in the mouse cerebellum. To further examine the SRC-1 function in the brain development, we investigated the localization of SRC-1 in mouse NSCs derived from the ganglionic eminence at embryonic day 12.5 and the expression profiles during differentiation of NSCs. As a result, SRC-1 expression was detected in nestin-positive neural stem cells. Following to differentiation, SRC-1 expression was increased in neural lineage cells but not in glial lineage cells. These results raised the possibility that SRC-1 may be involved in gene regulation for neuron specific development from NSCs. [Jpn J Physiol 55 Suppl:S208 (2005)]
