日本生理学会大会発表要旨集
日本生理学会大会発表要旨集
セッションID: 3P2-122
会議情報
小脳顆粒細胞で合成される分泌タンパク質、Cbln1は小脳のシナプス形成と可塑性に不可欠である
*平井 宏和宮崎 太輔三浦 会里子渡辺 雅彦モーガン ジェームス アイ柚崎 通介
著者情報
キーワード: Cerebellum, Purkinje cell, Cbln1, synapse, LTD
会議録・要旨集 フリー

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Cbln1 is the prototype for a family of four brain-specific proteins (Cbln1-Cbln4) of unknown function that was first identified by virtue of its harboring a naturally occurring 16 amino acid peptide, cerebellin. Cbln1 is a cerebellum-specific protein and structurally related to the C1q and Tumor Necrosis Factor families of proteins. We show here that Cbln1 is secreted from cerebellar granule cells as a glycoprotein and is essential for three processes in cerebellar Purkinje cells: the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and the induction of long-term depression at parallel fiber-Purkinje cell synapses. Interestingly, the behavioral, physiological and anatomical phenotype of cbln1-null mice precisely mimics loss-of-function mutations in the orphan glutamate receptor, GluR&delta2, a gene selectively expressed in Purkinje neurons. Therefore, Cbln1 secreted from presynaptic granule cells may be a component of a previously undocumented trans-neuronal signaling pathway that controls synaptic structure and plasticity. [J Physiol Sci. 2006;56 Suppl:S167]
著者関連情報
© 2006 日本生理学会
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