抄録
It is known that stress-induced hyperthermia is attenuated by intraperitoneal administration of antipyretic drugs. To investigate the site of action of antipyretic drugs on stress-induced hyperthermia and motor activity, adult male rats were subjected to cage switch stress or 30-min immobilization and administrated intra-preoptic/anterior hypothalamic (PO/AH) or intraperitoneal antipyretic drugs. The intraperitoneal administration of sodium salicylate significantly attenuated the hyperthermia induced by cage switch compared with saline group, but the intra-PO/AH administration of sodium salicylate did not attenuate the hyperthermia induced by cage switch compared with saline group. The intraperitoneal administration of acetaminophen slightly attenuated the hyperthermia induced by cage switch compared with saline group, but there was no significant difference. When rats were subjected to 30-min immobilization, stress-induced hyperthermia was significantly attenuated by intraperitoneal administration of sodium salicylate compared with saline group. Furthermore, the intraperitoneal administration of sodium salicylate induced hypothermia during several hours. These data suggest that stress-induced hyperthermia is not mediated by central nervous system and the stronger stressor may induce the production of prostaglandin during several hours. [J Physiol Sci. 2006;56 Suppl:S229]
