日本生理学会大会発表要旨集
日本生理学会大会発表要旨集
セッションID: 3SF33-2
会議情報
運動時循環機能の恒常性維持における骨格筋内情報の役割
*時澤 健水野 正樹村岡 功
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会議録・要旨集 フリー

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Exercise causes an increase in blood flow to active muscle and a decrease in vascular conductance in non-active muscle to meet a metabolic demand in the exercising muscle. Several neural mechanisms, such as arterial and cardiopulmonary baroreflex, central command and a feedback from skeletal muscle, are involved in maintenance of circulatory homeostasis. We now focus on the role of feedback signal from skeletal muscle via afferents arising from muscle mechanoreceptor and metaboreceptor. In single limb, post-exercise muscle ischemia which is conducted by circulatory cuff occlusion on the exercised arm decreased vascular conductance in non-active muscle via arm metaboreceptor activation. Simultaneous post-exercise muscle ischemia in the lower limb attenuated the decreased vascular conductance in non-active muscle (Tokizawa et al., Exp Physiol, 2006). Further passive muscle stretch or venous occlusion assumed to activate mechanoreceptor in the lower limb suppressed the decreased vascular conductance in non-active muscle (Tokizawa et al., J Appl Physiol, 2004a,b). These inhibitory effects on vasoconstriction in non-active muscle might play an important role to maintain circulatory homeostasis against excessive cardiovascular response during exercise when the feedback signal from multiple limbs occurred. [J Physiol Sci. 2007;57 Suppl:S51]
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© 2007 日本生理学会
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