抄録
Recently,it has been reported that the administration of granulocyte colony-stimulating factor (G-CSF) stimulated the angiogenesis and the regeneration of injured cardiac muscles by the mobilization of bone marrow stem cells(BMSCs).It has been suggested that BMSCs may participate in the regeneration of injured skeletal muscles.Therefore,the present study was performed to investigate the effects of G-CSF administration on the regenerative process of injured mammalian skeletal muscles in vivo.The effects of muscular activity-depression on the regeneration of skeletal muscles were also investigated. Male mice (C57BL/6J) were divided randomly into 7 groups:(1)cage control,(2)administration of G-CSF,(3)cardiotoxin(CTX)-injected(CX),(4)administration of G-CSF and CTX-injected(GX),(5)immobilized,(6)administration of G-CSF and immobilized,and (7)administration of G-CSF,CTX-injected and immobilized(GXI) groups.CTX was injected into tibialis anterior(TA) muscles of both limbs in CX,GX and GXI groups.We gave first injection of G-CSF 3 days before CTX-injection,and the administration was repeated for 8 consecutive days.TA muscles were dissected 7,14 and 28 days after CTX-injection.Results suggested that G-CSF may facilitate the regeneration of injured and immobilized skeletal muscles. [J Physiol Sci. 2007;57 Suppl:S94]
