ラットにおけるフランキンセンスエッセンシャルオイルの抗ストレス効果

抄録

The essential oils have been used to reduce tensions from some stressful conditions that might cause insomnia. The aim of this study was to examine whether frankincense oil affects plasma levels of corticosterone (CS) and biological antioxidant potential (BAP) as well as glutathione (GSH) concentrations of sleep deprived rats. Male SD rats (12-h light and 12-h dark) were used. Group A (control) and group B rats (sleep deprived between 9:00 to 15:00) received one drop (0.05ml) of jojoba oil as a control or frankincense oil as an experimental oil at every hour from 10:00 to 15:00 under sleep monitoring. Blood samples were collected to measure the CS by ELISA and the reactive oxygen metabolites and BAP by FRAS, respectively. The GSH levels in CSF were measured by HPLC. Blood CS levels were higher in sleep-deprived rats than non-sleep deprived rats. Frankincense induced dose-dependent suppression of CS comparing with the jojoba treated rats. Frankincense treated rats also demonstrated dose dependent suppression of BAP comparing with the jojoba treated rats. Body weight decreased in the frankincense group. The amount of wakefulness was increased, and slow wave sleep was decreased by frankincense oil comparing to the jojoba oil, while paradoxical sleep did not show any change. These results suggest that frankincense oil more likely improve the anti-stress effect, anti-dote effect and sleep compensation effect. [J Physiol Sci. 2007;57 Suppl:S192]