抄録
Melanosomes increases in melanocytes in response to the DMSO or the anticancer agents. This process is considered as the cytoprotective mechanisms against the cytotoxic chemicals or reactive oxygen spices because such agents can be captured by melanosomes and excluded by the exocytotic process.We already reported that the melanogenesis increased in B16 melanoma cells in thelow-glucose culture media without the cell damage. In this study we analyzed the responses of B16 cells against different types of cytotoxic stress in the low-glucose culture media and found that Hypoxia-inducible factor-1 (HIF-1) was induced in the low-glucose conditions by RT-PCR methods and the resistance against the hydrogen peroxide increased in comparison with the normal-glucose conditions. [J Physiol Sci. 2008;58 Suppl:S206]
