Machining is carried out on the assumption of machine tool stability, but machine tools do not stay in good running condition forever. They have components that deteriorate over time, sometimes causing the machine tool to break down. The machine tool may then have to be taken out of service for a lengthy time, forcing changes in plans and delays in production. Maintenance measures to prevent such occurrences include periodic replacement of components and periodic diagnosis. This study focused on the diagnosis of machining center failures. Maintenance data collected from die machining centers over a period of 11 years were analyzed. The analysis uncovered points at which failures were likely to occur, points at which periodic diagnosis is necessary, and points and components deserving priority for improvement. Specifically, the standardized variation of the failure data of each machining center was calculated, the degrees of the effects of different factors were obtained, and factors requiring attention were chosen. These results will be applied in machining center maintenance.