パップ剤清涼感のパラメータ設計による検討

抄録

This　is　a　parameter　design　study　on　the　formulation　of　cool-feeling　plasters. Plasters　have　been　used　for　a　long　time　as　anti-inflammatory　and　analgestic agents　as　well　as　bruise　and　sprain　treatments　in　orthopedics.　The　quality　of plasters　must　be　evaluated　from　the　pharmacological　viewpoints　such　as　antiinflammatory　and　analgestic functoins.　However,　cool-feeling　is　considered　to　be an　important　factor　to　help　achieving　the　pharmacological　effects. One　of　the　objectives　in　this　study　was　to find　the　relationship　between　plaster formulation　and　cool-feeling.　Another　objective　was　to　compare　the　difference between　the　results　form　consumer　feedback　and　the　test　results　from　specialy trainde　panelists　provided　by　the　manufacturer.　Some　methods　were　suggested to　narrow　down　the　difference.　To　quality　cooling-feeling,　skin　surface　temperature　and　skin　penetration　of　cooling　agent　in　the　plaster　were　measured.　The study　showed　cooling　agent　α　contributed　the　most,and　time　passage　had　significant　effects.　Little　relationship　between　cool-feeling　and　physical　measurements such　as　skin　temperature　and　cooling　agent　penetration　was　observed.　Such　findings　were　considered　to　be　useful　for　the　future　development　of　plasters.