Radiation Environment and Medicine
Online ISSN : 2432-163X
Print ISSN : 2423-9097
ISSN-L : 2423-9097
Presentation Abstracts
Possible Adverse Effects of Gadolinium-based Contrast Agent Exposure in Developing Brain
Noriyuki Koibuchi
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ジャーナル フリー

2025 年 14 巻 1 号 p. 45-

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Gadolinium (Gd)-based contrast agents (GBCAs) are commonly used to enhance magnetic resonance imaging (MRI) to increase the diagnostic yield. Although severe adverse ef fects of GBCAs in offspring when administered during pregnancy or lactation have not yet been reported, the tissue retention of total Gd after GBCAs exposure has been detected in the skin, liver, kidney, lung, heart, bones and brain. In the central nervous system, Gd retention has been observed in various brain regions, including the hippocampus, cerebellum, dentate nucleus, and globus pallidus. Considering the fact that blood-brain-barrier is not complete during pregnancy and lactation, it is reasonable to speculate that Gd retention may be greater if fetus and/or newborn are exposed to GBCAs during such periods. However, the ef fects of fetal/neonatal GBCA exposure on brain function and development have not yet been fully studied. Our group examined the effect of GBCA exposure using in vivo (mouse) and in vitro preparation. GBCA was detected from offspring brain after perinatal exposure, and in breast milk. Perinatal GBCA exposure disrupted motor coordination and spatial memory with decreased expression of several AMPA and NMDA receptor subunits. In astrocyte culture, GBCA accelerated cellular migration by modulating actin rearrangement through activating integrin α vβ3. In primary cerebellar culture, GBCA increased thyroid hormone-activated Purkinje cell dendritic arborization. Furthermore, GBCA augmented ligand-dependent thyroid hormone receptor-mediated transcription. These results indicate that perinatal GBCA exposure may disrupt brain development at least in part through disrupting integrin α vβ3-mediated and/or thyroid hormone receptor mediated pathway. The use of GBCAs in pregnant and lactating women may be avoided unless absolutely necessary.
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© 2025 Hirosaki University Press.
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