Historical Overview of the Established Technique of PET Tracers Approved by the Sub-committee on Medical Application of Cyclotron-Produced Radionuclide, Medical Science and Pharmaceutical Committee of the Japan Radioisotope Association

Abstract

The Medical Science and Pharmaceutical Committee of the Japan Radioisotope Association proposed to establish the national guidance for the clinical use of radiotracers labeled with short-lived positron emitting radionuclide in November, 1980, and started the Sub-committee on Medical Application of Cyclotron-Produced Radionuclide(re-named as Sub-committee on Application of Positron Nuclear Medicine in November, 2005). This sub-committee served to publish “recommendations on clinical use of ultra-short lived radionuclide produced by accelerators in medical institution or medical research facility”. It approved the radiotracers, which showed safety and clinical value, as established technique, and set the standards for production and quality control of the tracers. A total of 15 tracers have been approved as established technique.