2019 Volume 68 Issue 10 Pages 701-707
We introduce the results about the relative biological effectiveness (RBE) using HIMAC. Carbon-ion therapy is rated higher concerning the quality of life (QOL) than photon therapy because it has a strong cancer control ability and is considered to be a low-invasive method. It is important to evaluate the dose and to know the relations of linear energy transfer (LET) and RBE for understanding a useful effect of carbon-ion therapy. In this review, we summarize the current status and the meaning of the RBE concept in carbon-ion therapy and highlight outstanding issues.