8.2.6　Fractionation in Carbon-Ion Therapy

Abstract

In carbon-ion therapy, superiority of the physical dose distribution leads to a reduction in the number of fractions or may even allow hypofractionation. Several clinical trials are currently underway to evaluate the clinical effect of fractionated carbon-ion therapy. However, the biological effects of fractionation in carbon-ion beams hasn’t been investigated in detail. In this review, we will summarize the meaning of the fractionation and introduce mainly about previous study and our knowledge in the biological effects of fractionation using HIMAC.