RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Section 8 [Radiation Biology] Contribution of HIMAC for Radiation Biology
8.2.8 Effect of carbon ions on carcinogenesis
Tatsuhiko ImaokaMayumi NishimuraKazuhiro DainoYoshiya ShimadaShizuko Kakinuma
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JOURNALS OPEN ACCESS

2019 Volume 68 Issue 10 Pages 741-748

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Abstract

Heavy ion radiotherapy is expected to reduce the risk of second cancer by decreasing exposure of normal tissues to radiation. Emerging studies have attempted to predict the risk of second cancer after carbon ion radiotherapy based on dose assessment, the epidemiologically-identified risk of photon radiation, and assumptions about the relative biological effectiveness (RBE) of carbon ions. Nevertheless, large uncertainty remains in the choice of RBE of carbon ions in inducing cancer. The present article summarizes carcinogenesis experiments performed in animals using HIMAC. These animal experiments have yielded RBE values for selected tissues, beam types, and age at the time of irradiation. The results indicate potentially variable RBE which depends on tissues, ages, and dose levels. A few additional studies have attempted to identify molecular alterations in tumors induced by carbon ions. Thus, more comprehensive animal carcinogenesis studies are needed.

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© 2019 Japan Radioisotope Association
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