RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Distribution of Gold and Bismuth in Rats Subcutaneously Transplanted with Yoshida Sarcoma, and Relations between the Uptake Ratio of Various Labeled Compounds into the Maignant Tumor and Their Binding Capacity to the Protein
Atsushi ANDOKin-ichi HISADA
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1971 Volume 20 Issue 7 Pages 321-326

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Abstract

Affinity of gold and bismuth for the malignant tumor was examined;, using the rats which were subcutaneously transplanted with Yoshida sarcoma. And the relations between the uptake ratio into the malignant tumor and the binding capacity to the protein were investigated in the various compounds of mercury, bismuth, gold, gallium, indium, scandium and zinc.
The compounds of gold and bismuth had strong affinity for the malignant tumor as well as for the kidney. This nature of gold and bismuth for the malignant tumor and the kidney was very much similar to the nature of Hg-compounds for the malignant tumor and the kidney. The binding capacity to the protein was approximately in proportion to the uptake ratio of the compounds of mercury, gold, and bismuth into the malignant tumor. But in the uptake of the compounds of gallium, indium and scandium into the malignant tumor, the binding capacity to the protein did not seem to play an important part.
There was a group of the compounds in which the binding capacity to the protein was weak and the uptake ratio into the malignant tumor was small, but there was no compound in which the binding capacity to the protein was strong and the uptake ratio into the malignant tumor was small
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