Studies on Liver and Spleen Scintigraphy by ¹³¹I-Micro-Aggregated Albumin (¹³¹I-MIAA)

Abstract

¹³¹I-MIAA (Daiichi Radioisotope Labs., Ltd., particle size: 1-3μ) was compared with¹⁹⁸Au-colloid using liver and spleen scintigraphy.
The disappearance of¹³¹I-MIAA was 2.5 hours in liver and 3.5 hours in spleen. Suitable time of scintigraphy was from 10 min to 1 hour after intravenous injection.
The radiation dose with¹³¹I-MIAA to liver was decreased to 1/40 of that with¹⁹⁸Au-colloid and¹³¹I-MIAA was more localized to spleen in hepatosplenopathy. Therefore, it is useful for the reagent of scintigraphy for spleen than ⁵¹Cr or ²⁰³Hg-MHP, considering radiation dose to spleen and kidney.
The spleen-liver RI accumulation ratio calculated with¹³¹I-MIAA about various diseases showed more separative values than that with¹⁹⁸Au-colloid, so it seemed to be valuable for diagnosis and estimation of disease.