Role of Inflammation in Tumorous Accretion of Radiopharma-ceuticals: Experimental Studies with ⁶⁷Ga, ¹⁶⁹Yb, ¹¹¹In, ^99mTc-Pertechnetate, ^99mTc-Bleomycin, ⁵⁷Co-Bleomycin and ¹⁹⁸Au-Colloid

Abstract

Both ⁶⁷Ga and ¹¹¹In are concentrated in tumor and inflammatory lesions as well. Research in these regards was extended to radiopharmaceuticals that had recently been introduced: ¹⁶⁹Yb-citrate, ^99mTc-Pertechnetate, ^99mTc-Bleomycin, and ⁵⁷Co-bleomycin.
All of them revealed affinity to the experimental V2 carcinoma in the rabbit. Typhoid vaccine-induced, polymorphonuclear infiltrates also concentrated these radio-pharmaceuticals, too.
Inflammatory concentration of the tumor-imaging agents would lead to a false positivity. However, it should also be bore in mind that inflammatory changes, bacterial or aseptic, accompanying the tumorous lesions would increase deposition of the agents in the such lesions.