Distribution of ⁶⁷Ga-citrate in Tumor Tissues and Various Organs—Macroautoradiographic and Scintigraphic Studies—

Abstract

Localization of ⁶⁷Ga in various tissues was demonstrated by whole-body autoradiography of tumor-bearing mice in order to obtain comprehensive information which would aid in making more accurate interpretations of clinical scintigrams.
The macroautoradio grams (ARG's) showed the most intense accumulation of ⁶⁷Ga in the reticuloendothelial tissues, the wall of the intestinal tract and tumor tissues.
⁶⁷Ga nonspecifically accumulated in the abdominal region and was apparently excreted mostly from the kidneys and from the mucosa, of the intestinal tract. In the reticuloendothelial system such as bone marrow, liver tnd lymph nodes were sometimes difficult to distinguish from the lung tumor. In the ⁶⁷Ga-scintigram the high uptake of ⁶⁷Ga was seen in these organs. Tumor in the lung could be readily detected as the alveolar structure is occupied with a considerable amount of air and has much, lawer activity per unit volume in the normal.lung tissue. Thus the application of ⁶⁷Ga in autoradiography in experimental animals provided useful information which should assist in analyzation of routine ⁶⁷Ga-scintigrams in patients with neoplastic diseases.