1981 Volume 30 Issue 5 Pages 263-267
A new method for measurement of 24-hr whole-body retention (WBR) of 99mTc-MDP, using a thyroid uptake probe was established and its clinical significance was evaluated in various bone diseases.
(1) Reproducibility of 24-hr WBR in 9 patients was very good. Correlation coefficient was 0.997 and coefficient of variability was only 1.83%.
(2) Radiochemical purity of 99mTc-MDP was 97.8±0.7% (n=5), indicating no significant inter-lot variations.
(3) 24-hr WBR of normal adult males (n=5) was 30.0±4.9%, which was significantly elevated compared to the reported 99mTc-HEDP WBR of 19.2±1.7%. Whole-body retentions of chronic renal failure, metastatic bone disease and hyperthyroidism groups were significantly elevated compared to that of the normal group. However, WBR of steroid-induced osteoporotic group was significantly decreased.
Based on these results, this thyroid uptake probe method was simple, reproducible and accurate to measure 24-hr WBR of 99mTc-MDP. Quantification of WBR of 99mTc-MDP was of great clinical value to diagnose metabolic bone disease and to follow-up metabolic and metastatic bone diseases.
