Disposition of Suprofen in Rats Following Intravenous Injection

Abstract

Distribution and excretion of DL-2- (4- (2-thienylcarbonyl) phenyl) propionic acid (suprofen) were evaluated in male and female rats following intravenous (iv.) injection, of labeled suprofen. The radiometric findings following i.v. administration of 2 mg/kg of ³H-suprofen to male and female rats showed similar patterns of blood level and excretion of the radioactivity. Elimination, of ³H-suprofen from the blood was rapid; most of the radioactivity Was excreted in the urine and, a portion, inn the feces within 24h nftee injection. After Brats with btliary fistulas were givenn an i.v, dose of 2mg/kg of ³H-suprofen, approximately half of the, dose was excreted in the bile during 48 h. The only tissues with concentrations higher than that in they plasma were those involved in metabolism and excretion (liver end kidney) ; other tissue, levels were all very low and there was no evidence of accumulation of drug-related pnateral in any tissue.