Distribution of ²⁰¹Tl in the Blood

Abstract

Thallium-201 distribution in the blood was investigated both in vivo and in vitro. Thal-lium-201 was distributed into the erythrocytes and plasma with the ratio of 1.4±0.3 to 1.0, immediately after its administration. The uptake of ²⁰¹Tl into the erythrocytes in vitro were affected by the incubation temperature and the presence of ouabain and KCl; indicating that the ²⁰¹Tl was uptaken into cells partly through their membranes Na, K-ATPase. Erythrocytes could retain ²⁰¹Tl in it, whereas ²⁰¹Tl was present as free ion in the plasma. Thallium-201 was flew out of erythrocytes into the plasma, keeping the ratio of ²⁰¹Tl in erythrocytes/plasma to be 1.9±0.2/1.0.