1988 Volume 37 Issue 2 Pages 95-98
To clarify clinical evaluation of highly sensitive thyroid stimulating hormone (TSH) immunoradiometric assay (IRMA) using RIABEAD II kit, we measured serum TSH and its changes after TRH test in normal subjects and patients with hyperor hypo-thyroidism due to Grave's disease, TSHproducing pituitary adenoma and chronic thyroi-ditis or Ref etof's syndrome. In 12 normals, basal TSH (0.23 -1.85μIU/ml) increased in 2.29 -18.85μIU/ml 30 min after TRH test. In patients whose serum TSH and thyroid hormone showed less than 0.10μIU/ml and more than normal level, respectively, no response of TSH to TRH was observed, while in patients whose serum TSH and thyroid hormone showed more than 3.5μIU/ml and less than normal level, respectively, hyperresponse of TSH to TRH was observed. In patients with hyper-or hypo-thyroidism, changes in serum TSH after treatment were normalized a few months later after normalizing of thyroid hormone. In patients with TSH producing pituitary tumor or Ref etof's syndrome, serum TSH increased. These results show that serum TSH using IRMA- (RIABEAD II) kit indicates a precise function of pituitary TSH.
