Relation between Blood Clearance and Hepatic Uptake of ^99mTc-Phytate in Rats with Hepatic Injury

Abstract

The relation among the blood clearance of ^99mTc-phytate (^99mTc-P), the hepatic uptake of^99mTc-P and the severity of hepatic injury was investigated by using the rats with carbon tetrachloride (CCl₄), D-galactosamine (Gal N), α-naphthylisothiocyanate (ANIT) or DL-ethionine (EthN) induced hepatic injury.
After the administration of CCl₄, GalN or ANIT, serum GPT activity increased significantly with the increase of dose level, and the degree of this increase was in the order: GalN>CCl₄>ANIT. However, the mild increase in serum GPT activity was observed after EthN administration. The blood clearance rate of^99mTc-P and the hepatic uptake ratio of ^99mTc-P decreased with the increase of dose level after CCl₄, GalN or ANIT administration, but significant changes were not found after EthN administration. The degree of decrease in the blood clearance rate of^99mTc-P was in the order: GalN≅CCl4>ANIT, and the degree of decrease in the hepatic uptake ratio of^99mTc-P was in the order: GalN≅CCl⁴>ANIT.
These results suggest that the disorder in the hepatocytes may be one of causes for inducing the decrease in the hepatic uptake of^99mTc-P, and the consequence of this decrease may induce the decrease in the blood clearance of^99mTc-P.