Absorption, Distribution, Metabolism and Excretion of N-Cyclohexyl-2-benzothiazyl Sulfenamide (CBS), a Vulcanizing Accelerator, in Rats.

Abstract

Absorption, distribution, metabolism and excretion were studied in rats following a single oral administration of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) at a dose of 250 mg/kg. About 65% and 24% of the dose were excreted into urine and feces, respectively, for 3 days after administration of labeled CBS (cyclohexyl-¹⁴C) Biliary excretion amounted to about 5 % of the dose for 3 days. While about 92% of the dose was recovered in urine and feces at a ratio of 1: 1 within 3 days when ¹⁴C-2CBS was given.
No specific organ-affinity was observed in distribution study. Cyclohexylamine and 2-mer-captobenzothiazole were identified as urinary metabolites.