甲状腺疾患における99mTc-N- (2, 6-ジエチルフェニルカルバモイルメチル) イミノ二酢酸の肝の代謝排泄遅延について ―Deconvolution法による解析―

丹野 宗彦; 山田 英夫; 井手 宏; 京増 芳則; 中山 雅文; 栗原 教光; 間島 寧興; 千葉 一夫; 高橋 龍太郎; 佐藤 忠広

doi:10.3769/radioisotopes.39.9

Abnormal Hepatobiliary Clearance of ^99mTc-N- (2, 6-Diethylphenylcarbamoylmethyl) iminodiacetic Acid in the Altered State of Thyroid

—by an Analysis of Deconvolution Method—

Munehiko TANNO, Hideo YAMADA, Norimitsu KURIHARA, Yoshinori KYOMASU, Masafumi NAKAYAMA, [in Japanese], Yasuoki MASHIMA, Kazuo CHIBA, Rhyutaroh TAKAHASHI, Tadahiro SATOH

Author information

Munehiko TANNO
Department of Nuclear Medicine and Radiological Science
Hideo YAMADA
Department of Nuclear Medicine and Radiological Science
Norimitsu KURIHARA
Department of Nuclear Medicine and Radiological Science
Yoshinori KYOMASU
Department of Nuclear Medicine and Radiological Science
Masafumi NAKAYAMA
Department of Nuclear Medicine and Radiological Science
[in Japanese]
Department of Nuclear Medicine and Radiological Science
Yasuoki MASHIMA
Department of Nuclear Medicine and Radiological Science
Kazuo CHIBA
Department of Nuclear Medicine and Radiological Science
Rhyutaroh TAKAHASHI
Department of Endocrinology Tokyo Metropolitan Geriatric Hospital
Tadahiro SATOH
Department of Endocrinology Tokyo Metropolitan Geriatric Hospital

Keywords: technetium-99m-N- (2, 6-diethylphenylcarbamoylmethyl) iminodiacetic acid, deconvolution, thyroid, mean hepatic transit time, thyroid hormone

JOURNAL FREE ACCESS

1990 Volume 39 Issue 1 Pages 9-15

DOI https://doi.org/10.3769/radioisotopes.39.9

Details

Abstract

Hepatobiliary clearance of ^99mTc-EHIDA was investigated in cases with altered thyroid function by deconvolution method. The results indicated that mean hepatic transit time of all control subjects revealed less than 10 minutes. On the other hand, mean hepatic transit time of cases with altered thyroid function revealed prolonged more than 13 minutes. Cases especially showing an elevated serum concentration of TSH compared with normal range (4.6 μU/ml) had a tendency of a high incidence of markedly prolonged mean hepatic transit time. These results suggest that thyroid hormone may inf uence on the hepatic metabolism of hepatobiliary radiopharmaceuticals. This phenomenon also could partly explain the cause of liver dysfunction seen in subjects with altered states.

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