Study on the Distribution of T Lymphocytes in Mice

Abstract

Distribution of T lymphocytes was studied using ¹²⁵I-labeled Thy 1.2 monoclonal antibody which is supposed to be specific to Thy 1.2 antigen presented on the surface of mouse thymocytes. It became obvious that radio-labeled T lymphocytes in mice distributed in the blood and almost all of the organs except brain and spinal cord. The autoradiographic analysis by a bio-image analyzer system revealed that particular accumulation of radio-labeled T lymphocytes was found in brown fat, subcutaneous tissue and spleen. Their accumulation peaks were observed at 14 and 17 days after administration of the radio-labeled monoclonal antibody, respectively.