Removal of ⁵⁴Mn from the Mouse Body by Dilution with Stable Manganese and by Chelation with DTPA

Abstract

⁵⁴Mn is one of the activation products generated in nuclear reactors. This study was carried out to find a method appropriate for the removal of ⁵⁴Mn. Intraperitoneal administration of stable manganese effectively promoted the excretion of ⁵⁴Mn from the mouse body. The efficacy for removing ⁵⁴Mn was estimated to be 56, 67, 77 and 82% for manganese doses of 0.3, 1, 3 and 10mg/ kg, respectively. Oral administration of stable manganese was also effective for the removal of ⁵⁴Mn, but the efficacy was inferior to that obtained by intraperitoneal administration because of low gastrointestinal absorption of manganese. Ca-DTPA and Zn-DTPA promoted the excretion of ⁵⁴Mn when administered 1 h after administration of ⁵⁴Mn, but these chelating agents had little effect when administered after 3 h or more. Zn-DTPA was less effective than Ca-DTPA. These results demonstrate that dilution with stable manganese is more effective than Chelation with DTPA for the removal of ⁵⁴Mn from the body.