RADIOISOTOPES

Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303

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Volume 48, Issue 6

Displaying 1-11 of 11 articles from this issue

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High-yield, Enzymatic Synthesis of ¹⁴C- or ³H-Labeled 1-O-Valproyl-β-D-glucopyranuronic Acid, the Main Metabolite of Valproic Acid in Human

Naotoshi YAMAMURA, Shigeki MURAMATSU, Kanae SUZUKI, Minoru UCHIYAMA, E ...

1999Volume 48Issue 6 Pages 383-389
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.383

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A simple and high yield synthesis of radiolabeled 1-O-valproyl-β-D-glucopyranuronic acid was developed with the use of UDP-glucuronosyltransferase. Valproic acid, UDP-glucuronic acid, and UDP-glucuronosyltransferase were incubated for 48h at an optimum pH of 8.5. The enzymatic synthesis followed by column purification gave 51.8% and 52.5% yields of ¹⁴C- and ³H- labeled 1-O-valproyl-β-D-glucopyranuronic acid, respectively. The radiochemical purities of the ¹⁴C- and ³H-labeled substances were 98.8% and 99.2%, respectively. In contrast, the chemical synthesis using 2, 3, 4, 6-tetrabenzyl-D-glucopyranose and valproic acid resulted in much lower yield (6.8%) .

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Removal of ⁵⁴Mn from the Mouse Body by Dilution with Stable Manganese and by Chelation with DTPA

Itaru SATO, Naonori MATSUSAKA, Shuji TSUDA

1999Volume 48Issue 6 Pages 390-396
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.390

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⁵⁴Mn is one of the activation products generated in nuclear reactors. This study was carried out to find a method appropriate for the removal of ⁵⁴Mn. Intraperitoneal administration of stable manganese effectively promoted the excretion of ⁵⁴Mn from the mouse body. The efficacy for removing ⁵⁴Mn was estimated to be 56, 67, 77 and 82% for manganese doses of 0.3, 1, 3 and 10mg/ kg, respectively. Oral administration of stable manganese was also effective for the removal of ⁵⁴Mn, but the efficacy was inferior to that obtained by intraperitoneal administration because of low gastrointestinal absorption of manganese. Ca-DTPA and Zn-DTPA promoted the excretion of ⁵⁴Mn when administered 1 h after administration of ⁵⁴Mn, but these chelating agents had little effect when administered after 3 h or more. Zn-DTPA was less effective than Ca-DTPA. These results demonstrate that dilution with stable manganese is more effective than Chelation with DTPA for the removal of ⁵⁴Mn from the body.

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Relations between Outdoor, Indoor ²²²Rn Concentrations and Wind Velocity, Wind Directions Measured at a Tall Apartment

Seiichi YAMAMOTO, Takao IIDA

1999Volume 48Issue 6 Pages 397-402
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.397

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²²²Rn concentrations were simultaneously measured at a beranda (outdoor) and a room (indoor) of a tall apartment for a week. Average ²²²Rn concentrations at the outdoor and indoor were 3.25 Bq/m³ and 19.8 Bq/m³, respectively. Correlation analysis showed significant negative relation between outdoor ²²²Rn concentration and wind velocity as well as wind directions from south and west. There observed a significant positive relation between indoor and outdoor ²²²Rn concentration as well as a negative relation between indoor ²²²Rn concentration and wind direction from west.

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How Indicative of the Long-term Data Are Annual and Monthly Mean Atmospheric Radon Daughter Concentrations Obtained from Measurements Made over a Few Years?

Susumu MINATO

1999Volume 48Issue 6 Pages 403-406
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.403

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Clearance Levels for Solid Materials

—Review for the Clearance Levels Derived by International Organizations and the Nuclear Safety Commission—

Minoru OKOSHI

1999Volume 48Issue 6 Pages 407-420
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.407

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Synchrotron Radiation. VI. Analyses of Biological Samples Using Synchrotron Radiation

6. Three-dimensional Structures of Antibody Fab and Fv Fragments and Their Recognition of Antigen Ligands

Yoshinori SATOW

1999Volume 48Issue 6 Pages 421-428
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.421

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[title in Japanese]

[in Japanese]

1999Volume 48Issue 6 Pages 429-430
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.429

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[title in Japanese]

[in Japanese], [in Japanese]

1999Volume 48Issue 6 Pages 431-432
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.431

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[title in Japanese]

[in Japanese]

1999Volume 48Issue 6 Pages 433-434
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.433

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[title in Japanese]

[in Japanese]

1999Volume 48Issue 6 Pages 435-437
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.435

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[title in Japanese]

[in Japanese]

1999Volume 48Issue 6 Pages 438-440
Published: June 15, 1999
Released on J-STAGE: March 10, 2011

DOIhttps://doi.org/10.3769/radioisotopes.48.438

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