2025 Volume 52 Issue 1 Pages 37-43
Objective: To promote walking independence in patients following intravenous tissue Plasminogen Activator (t-PA) therapy, we conducted a retrospective study to investigate the factors influencing the walking ability in patients who received t-PA therapy.
Methods: The participants were patients with ischemic stroke who were admitted in Hospital X between April 1, 2015 and September 30, 2020, received intravenous t-PA therapy, and underwent physical therapy during hospitalization. Patients were divided into two groups based on ambulatory independence at discharge from our hospital or upon transfer to another facility. A comparative analysis was conducted between both groups, followed by multiple logistic regression analysis of the factors that showed significant differences.
Results: There were 48 participants. Multiple logistic regression analysis revealed that age (odds ratio [OR]; 1.15, 95% confidence interval [CI]; 1.04–1.27, p<0.01) and the number of days from admission to the first walk (OR; 1.75, 95% CI; 1.08–2.84, p<0.05) were associated with ambulatory independence. The cutoff values were 80 years of age and six days from admission to the first walk.
Conclusion: In patients who received intravenous t-PA therapy, age and the number of days from admission to the first walk were suggested as factors influencing ambulatory independence.
