Article ID: 12523
Objective: This study aimed to clarify differences in the acquisition and timing of gross motor functions among Fukuyama congenital muscular dystrophy (FCMD) genotypes. The relationships between genotypes and each of the gross motor functions were also examined.
Method: The presence and timing of acquisition of each gross motor function by genotype were investigated retrospectively in 60 FCMD children, and the highest attained level, the age in months at which each gross motor function was acquired, and the associations with genotypes were statistically analyzed.
Results: The highest attained level was most often shuffling for homozygous types and sitting for compound heterozygous types. Compared to compound heterozygotes, homozygotes were younger (age in months) at the times of head control and sitting acquisition, with higher maximum attainment levels being associated with earlier acquisition of lower gross motor function levels. Significant correlations were also demonstrated between the time of acquisition of each gross motor function, and logistic regression analysis yielded prediction equations for the probability of acquiring mobility with the age of head control acquisition and age of sitting acquisition as explanatory variables.
Conclusions: Several characteristics of gross motor development for each genotype in FCMD were recognized and the age of head control or sitting acquisition was suggested to be important for predicting mobility acquisition.
