EFFICACY OF COMBINATION THERAPY TRASTUZUMAB AND PACLITAXEL OF MULTIPLE BONE METASTASIS FOLLOWING BREAST CANCER SURGERY -A CASE REPORT-

Abstract

A 61-year-old woman underwent Bt+Ax+Ic+Mj for right breast cancer in May 1989. The pathological diagnosis was scirrhous carcinoma, n1β (4/9), ER (+), PgR (-), and she was placed on oral UFT and TAM for three years postoperatively. In May 1999, bone metastasis was detected in the left ilium. Four courses of CEF chemotherapy and radiation therapy (42 Gy) followed by weekly docetaxel therapy were administered, and the serum CEA level decreased from 9.0 ng/ml to 2.3 ng/ml. In September 2001, a compression fracture caused by bone metastasis in the right femoral neck was diagnosed, and an artificial femoral head replacement operation was performed. Trastuzumab 90 mg and paclitaxel 60 mg were concomitantly administered for two weeks because the primary and metastatic site were Herceptest 2+, and the CEA value decreased from 13.5 ng/ml to within the normal range, 2.2 ng/ml. Bone scintigraphy did not show complete resolution of the metastatic sites, but no new lesions appeared for 20 months. The combination of trastuzumab and paclitaxel was effective against postoperative multiple bone metastasis in this case.