Abstract
Thrombocytopenic effect of the ITP patient's serum on rabbits was investigated, in comparison with the serum from normal adult and patients with secondary thrombocytopenia.
The decrease of rabbit platelets after infusion of patient's serum was most remarkable and continued more than 24 hours since the beginning of injection.
The number of megakaryocytes in the bone marrow of rabbits rapidly decreased and their platelet production also depressed 4 and 24 hour after injection.
There was a definite correlation between the thrombocytopenic effect of patient's serum and their clinical course.
From the results mentioned above, it was concluded that the demonstration of thrombocytopenic factor in the patient's serum was useful method for the diagnosis of ITP.
