Abstract
Two cases of them had complications; one aortic regurgitation, and the other diabetes mellitus and a bladder tumor. The diagnosis of myeloma was given by the serum protein fractionation and immunoelectrophoresis.
X-ray examination revealed punched-out areas and thin cortices of the skull and, in addition, osteoporosis of ribs in one of them. In all cases a compression fracture, spondylitis ancylopoietica or osteoporosis of the lumber vertebra was found.
In myelogram an increase of plasma cell was found, but no plasma cell in the blood. There were moderate anemias. Serum showed elevated levels of B.U.N., uric acid and total protein, but no cryoglobulin. All the serum electrophoretic patterns showed a high, sharp peak in γ region. Urine of two cases with Bence Jones proteinuria showed similar electrophoretic pattern to the serum. The other case had neither a sharp peak in γ region on electrophoresis nor Bence Jones protein.
In immunoelectrophoresis every case presented a larage, diffuse IgG bow, and disappearance or decrease of IgA and IgM was observed. Lastly in the immunoelectrophoresis using anti-K and anti-L rabbit serum, a deposit line strongly reacting with anti-K serum was found.
From these facts, these three caces were concluded as IgG myeloma of K-type.
